Endocrine Abstracts

Introduction and aims: Thionamide may have immunosuppressive mechanisms. However, data suggest restoration of the immunological regulation as patients return to the euthyroid state may better explain remission, How successfully patients are kept euthyroid during a course of antithyroid drug therapy for Graves’ hyperthyroidism, and whether not continuously maintaining normal thyroid function is associated with a worse prognosis, is not known.Aims: 1)...

We have recently shown that patients with growth hormone (GH) excess (acromegaly) exhibit inadequately low intrahepatic lipid content (IHL) despite marked insulin resistance. GH might increase mitochondrial oxidation capacity thereby counteracting ectopic lipid accumulation; however, up-regulation of mitochondrial function has been reported in early stages of non-alcoholic fatty liver disease. Up to now, data on mitochondrial activity in patients with acromegaly are missing.</...

Background: Craniopharyngiomas (CP) are benign brain tumours presenting in childhood treated by tumour resection together with radiotherapy. In about half of the cured patients hypothalamic damage leading to eating disorders and obesity as well as to hypopituitarism, necessitating consequent hormone substitution therapy, is observed. Bariatric surgery is an efficient treatment strategy for morbid obesity. However, so far it is unknown, whether oral hormone substitution is hamp...